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KMID : 1141020190190010117
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Journal of Applied Oriental Medicine
2019 Volume.19 No. 1 p.117 ~ p.125
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The Root bark of Ulmus davidiana Ameliorates the Scopolamine-Induced Memory Impairments in Mice
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Kim Eung-Gyu
Jung Ji-Wook
Roh Seong-Soo
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Abstract
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Objectives : The purpose of this study was to characterize the neuroprotective effects of the water extracts of Ulmus davidiana var japonica on the learning and memory impairments induced by scopolamine.
Methods : The cognition-enhancing effect of Ulmus davidiana was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 ㎎/㎏, i.p.).
Results : A single treatment of Ulmus davidiana (50, 100 and 200 ㎎/㎏) significantly reversed the scopolamine-induced cognitive impairments in mice on the passive avoidance test in a does dependant manner (100 and 200 ㎎/㎏) without affecting the electric-shock induced behavior score. Ulmus davidiana (200 ㎎/㎏) also improved escape latencies in training trials and increased swimming times in the target zone of the Morris water maze (P < 0.05). On the Y-maze test, Ulmus davidiana (100 and 200 ㎎/㎏) also significantly reversed scopolamineinduced cognitive impairments in mice (P < 0.05).
Conclusions : The water extracts of Ulmus davidiana dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.
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KEYWORD
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Ulmus davidiana, learning and memory, scopolamine, dementia
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